What are the differences between Buprenex, Butrans, Buprenorphine, Suboxone, and Subutex?
All of these medications are similar in that they contain a shared active ingredient buprenorphine hydrochloride. They are all different medications with the exception of buprenorphine which is the active ingredient in all medications. There are subtle differences between each of the medications Buprenex, Buprenorphine, Suboxone & Subutex. The main differences are in the dosing, usage and marketing of the medications. Some contain additional active ingredients that make the drug combination useful for different purposes.
The table below is a basic summary of the differences between Buprenex, Butrans, Buprenorphine, Suboxone, and Subutex.
|Brand Name||Generic Name||Active Ingredients||Delivery Method||Marketing Towards||Distributer||Strength|
|Buprenex®||Buprenorphine||Buprenorphine HCI||Intravenous, Intramuscular||Typically cats & dogs for pain||Reckitt Benckiser Pharmaceuticals Inc||.3mg in 1ml|
|Suboxone®||Buprenorphine, Naloxone||Buprenorphine HCI & Naloxone HCI||Sublingual Tablets||Humans for Opiate Dependence||Reckitt Benckiser Pharmaceuticals, Inc.||8mg with 2mg / 2mg with .5mg|
|Subutex®||Buprenorphine||BUPRENORPHINE HCI & NALOXONE HCI||Sublingual Tablets||Humans for Opiate Withdrawal||Reckitt Benckiser Pharmaceuticals, Inc.||8mg / 2mg|
|Suboxone Film®||Buprenorphine, Naloxone||Buprenorphine HCI & Naloxone HCI||Sublingual Film||Humans for Opiate Dependence||Bryant Ranch Prepack||8mg with 2mg / 2mg with .5mg|
|Butrans®||Buprenorphine||Buprenorphine HCI||Transdermal System (through the skin via a patch)||Humans for Moderate to Severe Chronic Pain||Purdue Pharma||5 mcg/hour, 10 mcg/hour, and 20 mcg/hour.|
[notice] This information was compiled using many sources and should be used for entertainment purposes only. [/notice]
Buprenex is typically marketed for animals such as cats and dogs. Buprenex contains the same active ingredient as all buprenorphine medications. Buprenex does not contain Naloxalone like other versions of the drug because it is not intended to be used for withdrawal of opiates.
Proprietary / Brand Name: Buprenex
Generic Name: buprenorphine (byoo-pre-NOR-feen)
See Buprenex details
Active ingredients: buprenorphine HCI (buprenorphine)
A strong prescription pain medicine that contains an opioid (narcotic) that is used to treat moderate to severe around-the-clock pain.
Butrans is a partial opioid agonist product indicated for the management of moderate to severe chronic pain in patients requiring a continuous, around-the-clock opioid analgesic for an extended period of time. Each Transdermal patch is designed to deliver medication over a 7 day period.
BUTRANS is a rectangular or square, beige-colored system consisting of a protective liner and functional layers. BUTRANS is available in three strengths:
- BUTRANS 5 mcg/hour Transdermal System (dimensions: 45 mm by 45 mm)
- BUTRANS 10 mcg/hour Transdermal System (dimensions: 45 mm by 68 mm)
- BUTRANS 20 mcg/hour Transdermal System (dimensions: 72 mm by 72 mm)
Pharmacokinetic information on Butrans in Healthy Subjects, Mean (%CV)
|Single 7-day Application||AUCinf
|BUTRANS 5 mcg/hour||12087 (37)||176 (67)|
|BUTRANS 10 mcg/hour||27035 (29)||191 (34)|
|BUTRANS 20 mcg/hour||54294 (36)||471 (49)|
|Multiple 7-day Applications||AUCtau,ss
|BUTRANS 10 mcg/hour, steady-state||27543 (33)||224 (35)|
Suboxone is indicated for the treatment of opioid dependence. Suboxone contains Buprenorphine HCI and Naloxone HCI. Administer Suboxone sublingual film or tablets sublingually as a single daily dose. Suboxone film and tablets come in two sublingual dose sizes: 2 mg buprenorphine with 0.5 mg naloxone and 8 mg buprenorphine with 2 mg naloxone.
Tablets vs Film
Patients being switched between SUBOXONE (buprenorphine and naloxone) sublingual tablets and SUBOXONE sublingual film should be started on the same dosage as the previously administered product. However, dosage adjustments may be necessary when switching between products. Because of the potentially greater relative bioavailability of SUBOXONE sublingual film compared to SUBOXONE (buprenorphine and naloxone) sublingual tablets, patients switching from SUBOXONE (buprenorphine and naloxone) sublingual tablets to SUBOXONE sublingual film should be monitored for over-medication. Those switching from SUBOXONE sublingual film to SUBOXONE (buprenorphine and naloxone) sublingual tablets should be monitored for withdrawal or other indications of under-dosing. In clinical studies, pharmacokinetics of SUBOXONE sublingual film was similar to the respective dosage strengths of SUBOXONE (buprenorphine and naloxone) sublingual tablets, although not all doses and dose combinations met bioequivalence criteria.
Subutex is indicated for the treatment of opioid dependence. Subutex contains buprenorphine HCI and does not contain Naloxone like its’ brother Suboxone.
The pharmocokinetic properties of Suboxone and Subutex are very similar
|12.52(35)||20.22 (43)||34.89 (33)||32.63 (25)|
While each of these medications are similar, there are significant differences in the delivery, dosage, delivery and purpose. This information was compiled using many sources and should be used for entertainment purposes only.